Reevaluating the Substrate Specificity of the L-Type Amino Acid Transporter (LAT1)
نویسندگان
چکیده
منابع مشابه
Imaging the L-Type Amino Acid Transporter-1 (LAT1) with Zr-89 ImmunoPET
The L-type amino acid transporter-1 (LAT1, SLC7A5) is upregulated in a wide range of human cancers, positively correlated with the biological aggressiveness of tumors, and a promising target for both imaging and therapy. Radiolabeled amino acids such as O-(2-[(18)F]fluoroethyl)-L-tyrosine (FET) that are transport substrates for system L amino acid transporters including LAT1 have met limited su...
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ژورنال
عنوان ژورنال: Journal of Medicinal Chemistry
سال: 2018
ISSN: 0022-2623,1520-4804
DOI: 10.1021/acs.jmedchem.8b01007